Satsuki Kiryuuin and her Elite Four dominate Honnouji Academy, where rank brings more than status. Students at the top receive Goku Uniforms, special clothing that grants superhuman abilities. Ryuuko Matoi arrives at the school while investigating her father's murder, following her sole lead: the missing half of his invention, the Scissor Blade. But a crushing defeat by a uniformed student leaves her unable to challenge the academy's power structure.
Retreating to the ruins of her home, Ryuuko discovers Senketsu, a rare, sentient garment known as a Kamui, or God Clothes. Contact with her blood awakens Senketsu, which attaches itself to her and grants her immense power. With Senketsu and the Scissor Blade, Ryuuko takes on the Elite Four, hoping to reach Satsuki and find out who killed her father.