Holy Kuujou has 50 days before her newly awakened Stand consumes her. To save her, her son Joutarou, her father Joseph Joestar, and their allies must reach Cairo, Egypt, and destroy the immortal vampire behind her condition. Their mission takes them halfway around the world, with hostile Stand users fighting to stop them.
Until recently, Joutarou feared his own power so much that he refused to leave a Japanese jail despite having committed no crime. At Holy's request, Joseph came to help his grandson and explained that the apparent possessing spirit was a Stand: a physical manifestation of fighting spirit. A clash with Joseph's friend Muhammad Avdol forced Joutarou out of his cell and led him to begin learning control. Now he must use that power in a struggle whose failure threatens not only his mother, but humanity.