A meeting to sell Nathan Drake's ring erupts into violence in London, drawing Drake and Victor “Sully” Sullivan into conflict with Katherine Marlowe. Uncharted 3: Drake's Deception also revisits Drake's teenage years in Cartagena, where his attempt to steal Sir Francis Drake's ring leads to Sullivan becoming his mentor.
The central quest takes Drake into the Arabian Desert in search of the fabled Atlantis of the Sands. Uncovering the lost city's secrets leaves him fighting to survive and confronting his deepest fears.