A hand-grenade accident forces an undercover agent's twin brother to take his place in Total Overdose. The DEA pulls Ramiro Cruz out of jail and tells him that his brother Tommy has information about their father Ernesto's death, described as an alleged overdose. With Tommy injured, Ramiro must replace him in an operation targeting drug cartel leader Papa Muerte.
Ramiro's mission takes him through Mexico's criminal underworld. Combat combines third-person action with a combo system, special moves and a broad selection of weapons, accompanied by a Latin soundtrack.
