Resistance 2 follows Sgt. Nathan Hale as humanity makes its last stand in the United States after fighting the Chimera invasion in Europe. Hale faces two threats: the enemy forces he must fight and a virus inside his body that threatens to turn him into one of them. The single-player campaign includes a new weapons arsenal and giant boss encounters.
Separate from that campaign, eight players can take part in a standalone, class-based online co-op campaign. Competitive online multiplayer supports 60 players.