Humanity's migration to the Moon places X and his teammates at the center of Mega Man X8. The effort, known as the Jakob Project, uses an orbital elevator in the Galapagos Islands and new-generation Reploids built to assist space development.
When an elevator crashes during X's patrol, he finds what appears to be an army of Sigmas inside. Project director Lumine explains that they are Reploids using DNA copy data to change their shapes and appearances.