Deadpool casts the player as Wade Wilson in a self-aware adventure about a mercenary who coerces a studio into making a game about him, then defaces its script with red crayon.
His assignment to assassinate corrupt media mogul Chance White is interrupted by Mister Sinister, setting Wilson on a path of revenge. The conflict expands beyond the original contract as he uncovers a threat to humanity. Wolverine, Rogue, Domino and the time-travelling Cable help him oppose Sinister and his Marauders: Arclight, Blockbuster and Vertigo.