The search for Paleblood, a mysterious cure, brings the Hunter to the decaying Gothic city of Yharnam. In Bloodborne, the player slays beasts and investigates the source of the plague that has transformed the city's inhabitants.
After a blood transfusion, the Hunter awakens in the Hunter's Dream, a spectral realm where they are bound to serve forces they do not understand. The hunt moves between dream and reality as the Hunter seeks Paleblood, a way out of the Dream, and answers to the Healing Church's secrets.