Alien vs. Predator lets up to three players choose from four fighters: Major Dutch Schaefer, Lieutenant Linn Kurosawa, a Predator hunter and a Predator warrior. The group battles Xenomorph hordes and rogue human soldiers across several environments.
The conflict takes place in San Drad, California, where an Alien infestation has left Dutch and Linn cornered and abandoned by their superiors. Two Predators rescue them and propose an alliance to stop the infestation.